Infertility is the inability to become pregnant. It can have many causes, both physical and emotional, and can occur because of problems in the woman, man, or both. It is grouped into two categories: primary infertility, which refers to couples who have not become pregnant after at least one year of unprotected intercourse; and secondary infertility, which refers to couples who have been pregnant at least once but are not able to get pregnant now. A woman’s peak fertility occurs in her early 20s. After age 35, the chance that a woman can get pregnant drops considerably. Doctors treat infertility depending on the woman’s age and the cause.
UAB Medicine’s nationally recognized physicians have years of experience in diagnosing and treating both male and female infertility. We treat infertility with a team approach that includes a urologist, a reproductive endocrinologist, specialized nurses, and laboratory scientists. A variety of conventional treatments are available, including corrective microsurgery. For those who do not have a condition that can be treated, procedures such as intrauterine insemination or in vitro fertilization (IVF) may be used to help a couple get pregnant. Our fertility experts will determine a treatment plan that is best suited for each individual man and his partner. As a major center for research, UAB Medicine continues to investigate new advances in fertility treatment aimed at increasing the chances of conceiving healthy babies.
Find a Provider to Schedule an Appointment
- UAB Department of Obstetrics and Gynecology
- National Institutes of Health – Infertility and Fertility
- UAB Division of Reproductive Endocrinology and Infertility Services
Some couples are at increased risk for transmitting genetic diseases to their children. The disorders include hemophilia, Tay-Sach’s disease, Sickle Cell Anemia, Cystic Fibrosis, Down’s syndrome, and others.
Women over the age of 38 or those with recurrent miscarriage may be at risk for chromosomal abnormalities called aneuploidies. Preimplantation Genetic Diagnosis (PGD) allows the embryologist to screen embryos for these and many other genetic abnormalities.
PGD patients undergo in vitro fertilization to create embryos that will be transferred to the uterus. Once the embryos mature, the embryologist makes a small hole in the embryo’s outer membrane using a laser. A single cell is withdrawn for the PGD procedure(s) without damage to the embryo. Each cell contains the complete genetic makeup of the embryo.
The cell is examined for an abnormal number of chromosomes, using fluorescent in situ hybridization (FISH). FISH, enables the embryologist to count chromosomes and often identify other abnormalities.
The polymerase chain reaction (PCR) is used when damage, or disease, is suspected on a particular chromosome segment. The PCR duplicates and amplifies certain chromosome sections so that disorders can be seen.
Some diseases, such as hemophilia, are sex-linked meaning they are transmitted on the X chromosome. Because males have only 1 X chromosome but females have 2, these sex-linked diseases are more apparent in males. Hemophilia is an example of a sex-linked disease, meaning that males are the ones usually affected. FISH can be used to separate male and female embryos, and in this case, only female embryos would be transferred to the mother. The same applies if a chromosomal abnormality is seen using PCR in that only normal embryos would be transferred.
While no procedure is guaranteed to eliminate birth defects, there are many genetic diseases that can be identified using PGD and research continues to expand the list. Using PGD lowers the chances of genetic birth defects.
Speak to your physician about your options and browse the link below for more information
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