Tetralogy of Fallot

Tetralogy of Fallot is a rare, complex congenital heart defect, meaning that it is present at birth. It causes oxygen-poor blood and oxygen-rich blood to mix together, with both being pumped out of the heart and into the blood vessels. As a result, blood leaving the heart has less oxygen than is needed by the organs and tissues of the body, causing a condition called hypoxemia. Ongoing and long-term lack of oxygen causes cyanosis, a condition marked by a bluish color of the skin, lips, and membranes inside the nose and mouth.

Tetralogy of Fallot involves four heart defects: a ventricular septal defect, or a hole in the wall between the heart's two lower chambers; pulmonary stenosis, or the narrowing of the pulmonary valve (which carries blood from the heart to the lungs), causing it to not open fully; right ventricular hypertrophy, in which the muscle of the right ventricle is thicker than usual; and a defect in the aorta, the main artery that carries oxygen-rich blood from the heart to the body. Doctors repair this defect with open-heart surgery, either soon after birth or later in infancy.

Why UAB

Tetralogy of Fallot is a rare, complex congenital heart defect, meaning that it is present at birth. It causes oxygen-poor blood and oxygen-rich blood to mix together, with both being pumped out of the heart and into the blood vessels. As a result, blood leaving the heart has less oxygen than is needed by the organs and tissues of the body, causing a condition called hypoxemia. Ongoing and long-term lack of oxygen causes cyanosis, a condition marked by a bluish color of the skin, lips, and membranes inside the nose and mouth.

Tetralogy of Fallot involves four heart defects: a ventricular septal defect, or a hole in the wall between the heart's two lower chambers; pulmonary stenosis, or the narrowing of the pulmonary valve (which carries blood from the heart to the lungs), causing it to not open fully; right ventricular hypertrophy, in which the muscle of the right ventricle is thicker than usual; and a defect in the aorta, the main artery that carries oxygen-rich blood from the heart to the body. Doctors repair this defect with open-heart surgery, either soon after birth or later in infancy.

 

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CLINICAL TRIALS

UAB is an active participant in research and clinical trials for the diagnosis and treatment of tetralogy of fallot. We encourage you to speak to your physician about research and clinical trial options and browse the link below for more information.

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