Coronary Chronic Total Occlusion

A coronary chronic total occlusion is a total blockage in a coronary artery that has been present for at least three months. Coronary arteries are the blood vessels that supply blood and oxygen to the heart. If the complete blockage has been present for less than three months, it is called a total coronary occlusion. The blockage is caused by atherosclerosis, which is the buildup of fatty deposits and inflammatory cells (called plaque) on the inner walls of the arteries that restrict blood flow to the heart. Without adequate blood flow, the heart becomes starved of oxygen and vital nutrients it needs to work properly. When one or more of the coronary arteries suddenly becomes completely blocked, a hear t attack (injury to the heart muscle) may occur.

At one time, a coronary chronic total occlusion required coronary bypass surgery. Today, qualifying patients can be treated with a minimally invasive procedure called a percutaneous coronary intervention (PCI). Sometimes called a coronary angioplasty, the PCI process involves using a device comprised of guide wires and a catheter fitted with a balloon to break up the blockage, after which a small mesh tube called a stent is placed in the affected area to support the inner wall of the artery and help maintain blood flow. The relatively new treatment is less invasive and allows for a faster recovery than bypass surgery.


UAB Interventional Cardiology is an internationally recognized leader in cardiac services, combining compassionate, innovative patient care with the most advanced technology and basic and clinical research. The program makes use of catheterization, stenting, angioplasty, and other minimally invasive interventional treatments to unblock clogged arteries.

UAB is one of the first heart centers in the nation to use a new procedure called percutaneous coronary intervention of coronary chronic total occlusion, which allows many patients to avoid bypass surgery.

Interventional Cardiology provides both inpatient and outpatient consultative care at UAB Hospital and at The Kirklin Clinic of UAB Hospital. The UAB Heart and Vascular Center, located in UAB Hospital’s North Pavilion, is one of the largest centers of its kind in the Southeast, encompassing 55,000 square feet. It also is among the first of its kind to integrate multiple services including electrophysiology, interventional cardiology, neuro-interventional radiology, pediatric cardiology, and vascular interventional radiology.






Premature Ventricular Contraction

Premature ventricular contraction, or PVC, is a condition that causes an extra heartbeat or an abnormal heartbeat that occurs earlier than it should. This abnormality originates in the two lower chambers of the heart (the ventricles), but it also may occur in the upper chambers of the heart (the atria). Premature ventricular contraction often manifests as an additional heartbeat, followed by a pause then a stronger, quicker heartbeat. It may be described as a flutter, or the heart skipping a beat.

Premature ventricular contractions are very common in all age groups, and most people will experience them at some point in their lives. For normal, healthy people, the occasional period of premature ventricular contractions is no need for concern and typically does not require treatment. For those with an underlying health condition, such as heart disease, premature ventricular contractions may cause additional problems or be indicative of worsening conditions. PVC may be brought on by something as simple as excess caffeine, a change in the body's electrolytes, or medicines such as albuterol. More serious health conditions, such as pneumonia or COPD (chronic obstructive pulmonary disease), could trigger PVC as a result of having too little oxygen in the blood.


UAB is an active participant in research and clinical trials for the diagnosis and treatment of chronic total occlusion. We encourage you to speak to your physician about research and clinical trial options and browse the link below for more information.

View Clinical Trials