Chronic Myelogenous Leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia or chronic granulocytic leukemia, is an uncommon and slowly progressing cancer in which the bone marrow makes too many white blood cells. Normal bone marrow, the soft tissue in the center of bones where blood cells are formed, makes blood stem cells that mature over time. In CML cases, too many of these cells become abnormal granulocytes, or leukemia cells. As these cells build up in the blood and bone marrow, they push out healthy cells, leading to other issues such as anemia or infection. CML almost always occurs in patients of middle age or older and rarely is seen in children. Symptoms may include fatigue, unexplained weight loss, night sweats, and fever.


The UAB Medicine Leukemia Clinic utilizes state-of-the-art technology to screen for and treat leukemia. Our physicians are nationally recognized for their expertise and innovation in the field, and our research team is dedicated to improving treatments and, ultimately, finding a cure for these diseases. Because we are part of the O'Neal Comprehensive Cancer Center at UAB’s nationally recognized research programs, our patients may be eligible for medicines and treatments not available at other institutions in the region. Our Comprehensive Cancer Center is nationally recognized as one of the best in the country and is a leader in bone marrow transplantation. UAB Medicine's Bone Marrow Transplant Program is the only one in the state and has achieved a high level of success, even with difficult diagnoses.

A diagnosis of cancer can be stressful for patients, so we provide a nurse navigator to help organize your visit. The program streamlines your introduction to UAB Medicine by arranging for your medical records, setting your appointments, and guiding you through the process. This allows your treatment team to deliver more efficient care.




UAB is an active participant in research and clinical trials for the diagnosis and treatment of chronic myelogenous leukemia. We encourage you to speak to your physician about research and clinical trial options and browse the link below for more information.

View Clinical Trials