Aortic Periprosthetic Leak

Aortic periprosthetic leak, or aortic periprosthetic valve leak, is a condition that sometimes occurs following surgery to replace the heart's aortic valve with a mechanical valve. Periprosthetic essentially means "around the prosthetic," which in this case refers to the mechanical valve. Periprosthetic leakage (PPL) is one of the most common reasons a second surgery is required following valve replacement.

To understand why valve replacement is needed, it's important to know the function of the aortic valve. Normally, blood is pumped from the left chamber of the heart, called the ventricle, to the aorta, a large blood vessel that transports oxygen-rich blood throughout the body. The heart's aortic valve controls the flow of blood between the ventricle and the aorta by closing between beats (when the heart is at rest) to help prevent a backflow of blood into the heart. If the aortic valve malfunctions or fails to close properly, blood regurgitates or leaks back into the heart's ventricle, resulting in aortic valve regurgitation. This prevents the body from getting the proper amount of blood and requires the heart to work harder to pump the blood. Aortic valve regurgitation may then require surgery to replace the aortic valve with a mechanical or prosthetic valve.



With the first and largest comprehensive heart valve program in the state, UAB Medicine provides continuing care for patients who have or are at risk for valve disease. Our team of surgeons and cardiologists are among the nation’s most highly regarded physicians, and they provide a multidisciplinary approach to the diagnosis and treatment of valve disease. From aortic valve stenosis to mitral valve regurgitation, and from traditional open-heart surgery to the latest in minimally invasive procedures and robotic-assisted valve repair surgery, UAB patients benefit from our expertise in treating patients with valve disease.

The UAB Comprehensive Valve Program has built an impressive list of accomplishments in recent years. Our cardiologists and heart surgeons performed the first transcatheter aortic valve replacement (TAVR) in Alabama; to date UAB has performed more TAVRs than any other hospital in the state. As an added service, patients who have been told by non-UAB doctors that they need valve surgery can speak to a UAB valve surgeon for a second opinion.

Images and Videos


Related Conditions

This procedure may be used to treat or diagnose several different conditions. We have listed some of these conditions below for your convenience. Please note that this is not a comprehensive list and may vary depending on your specific diagnosis.


UAB is an active participant in research and clinical trials for the diagnosis and treatment of aortic periprosthetic leak. We encourage you to speak to your physician about research and clinical trial options and browse the link below for more information on clinical trials at

View Clinical Trials