UAB Medicine

Diabetes, Other - Overview

Type 1 and type 2 diabetes occur most often and are described as polygenic, which means several genes are causing it. In rarer forms, which represent about 1% to 2% of all cases, a single gene that has mutated can cause diabetes. The gene could be inherited or just mutate on its own. These diabetic conditions are called monogenic and all of them inhibit the body’s ability to produce insulin. Some of these include: permanent neonatal diabetes (PND), transient neonatal diabetes (TND), and the most common, maturity-onset diabetes of the young (MODY). Some of these respond to treatment, and some are mild enough to not need treatment, at least until later in life.

Diabetes can also show up during pregnancy, which is called gestational. An expectant mother would experience all the symptoms of diabetes, such as thirst and fatigue. The mother is not likely to be in danger, as the diabetes typically disappears after the birth. However, the health of the baby depends on the mother eating right and exercising to control the high blood sugar levels.
Services Performed
The diabetic clinics at UAB test and treat diabetes and its complications with a multidisciplinary approach.
  • Assessment of beta-cell function
  • insulin sensitivity
  • counter-regulatory responses to hypoglycemia
  • Oral Glucose Tolerance Testing (oGTT)
  • Frequently Sampled Intravenous Glucose Tolerance Test (fsIVGT)
  • Glucagon Stimulated C-Peptide
  • Mixed-Meal Tolerance Test
  • Insulin Tolerance Test
  • Hyperinsulinemic Euglycemic Glucose Clamp
  • Hyperglycemic Glucose Clamp
  • Hyperinsulinemic Stepped Hypoglycemic Clamp
  • Many other dynamic endocrine tests
Other tests
  • Pharmacokinetic
  • Metabolic
  • Energy expenditure
  • Anthropometric
  • Body composition studies
  • Performance of percutaneous fat
  • Muscle biopsy